diff --git a/sdk/ai/azure-ai-projects/samples/agents/sample_agents_basics_with_azure_monitor_tracing.py b/sdk/ai/azure-ai-projects/samples/agents/sample_agents_basics_with_azure_monitor_tracing.py
index b1a437b87846..f6cdad68298f 100644
--- a/sdk/ai/azure-ai-projects/samples/agents/sample_agents_basics_with_azure_monitor_tracing.py
+++ b/sdk/ai/azure-ai-projects/samples/agents/sample_agents_basics_with_azure_monitor_tracing.py
@@ -51,7 +51,7 @@
 
 with tracer.start_as_current_span(scenario):
     with project_client:
-        project_client.telemetry.enable()
+        #project_client.telemetry.enable()
         # [END enable_tracing]
         agent = project_client.agents.create_agent(
             model=os.environ["MODEL_DEPLOYMENT_NAME"], name="my-assistant", instructions="You are helpful assistant"
@@ -62,7 +62,7 @@
         print(f"Created thread, thread ID: {thread.id}")
 
         message = project_client.agents.create_message(
-            thread_id=thread.id, role="user", content="Hello, tell me a joke"
+            thread_id=thread.id, role="user", content="Hello, tell me a hilarious joke"
         )
         print(f"Created message, message ID: {message.id}")
 
diff --git a/sdk/monitor/azure-monitor-opentelemetry/CHANGELOG.md b/sdk/monitor/azure-monitor-opentelemetry/CHANGELOG.md
index 7687dd98dc0a..a8ce0f3b2026 100644
--- a/sdk/monitor/azure-monitor-opentelemetry/CHANGELOG.md
+++ b/sdk/monitor/azure-monitor-opentelemetry/CHANGELOG.md
@@ -4,6 +4,9 @@
 
 ### Features Added
 
+- Enable Azure AI Agents instrumentation
+    ([#40043](https://github.com/Azure/azure-sdk-for-python/pull/40043))
+
 ### Breaking Changes
 
 ### Bugs Fixed
diff --git a/sdk/monitor/azure-monitor-opentelemetry/azure/monitor/opentelemetry/_configure.py b/sdk/monitor/azure-monitor-opentelemetry/azure/monitor/opentelemetry/_configure.py
index c9910392fc19..0767e430370b 100644
--- a/sdk/monitor/azure-monitor-opentelemetry/azure/monitor/opentelemetry/_configure.py
+++ b/sdk/monitor/azure-monitor-opentelemetry/azure/monitor/opentelemetry/_configure.py
@@ -269,20 +269,31 @@ def _setup_additional_azure_sdk_instrumentations(configurations: Dict[str, Confi
         _logger.debug("Instrumentation skipped for library azure_sdk")
         return
 
-    try:
-        from azure.ai.inference.tracing import AIInferenceInstrumentor  # pylint: disable=import-error,no-name-in-module
-    except Exception as ex:  # pylint: disable=broad-except
-        _logger.debug(
-            "Failed to import AIInferenceInstrumentor from azure-ai-inference",
-            exc_info=ex,
-        )
-        return
+    instrumentors = [
+        ("azure.ai.inference.tracing", "AIInferenceInstrumentor"),
+        ("azure.ai.projects.telemetry.agents", "AIAgentsInstrumentor")
+    ]
 
-    try:
-        AIInferenceInstrumentor().instrument()
-    except Exception as ex:  # pylint: disable=broad-except
-        _logger.warning(
-            "Exception occurred when instrumenting: %s.",
-            "azure-ai-inference",
-            exc_info=ex,
-        )
+    for module_path, class_name in instrumentors:
+        instrumentor_imported = False
+        try:
+            module = __import__(module_path, fromlist=[class_name])
+            instrumentor_imported = True
+        except Exception as ex:  # pylint: disable=broad-except
+            _logger.debug(
+                "Failed to import %s from %s",
+                class_name,
+                module_path,
+                exc_info=ex,
+            )
+
+        if instrumentor_imported:
+            try:
+                instrumentor_class = getattr(module, class_name)
+                instrumentor_class().instrument()
+            except Exception as ex:  # pylint: disable=broad-except
+                _logger.warning(
+                    "Exception occurred when instrumenting using: %s.",
+                    class_name,
+                    exc_info=ex,
+                )