diff --git a/Library/Homebrew/ast_constants.rb b/Library/Homebrew/ast_constants.rb
index a2c1a5960649a..70b1ba829a8e4 100644
--- a/Library/Homebrew/ast_constants.rb
+++ b/Library/Homebrew/ast_constants.rb
@@ -43,6 +43,7 @@
   [{ name: :cxxstdlib_check, type: :method_call }],
   [{ name: :link_overwrite, type: :method_call }],
   [{ name: :fails_with, type: :method_call }, { name: :fails_with, type: :block_call }],
+  [{ name: :pypi_packages, type: :method_call }],
   [{ name: :resource, type: :block_call }],
   [{ name: :patch, type: :method_call }, { name: :patch, type: :block_call }],
   [{ name: :needs, type: :method_call }],
diff --git a/Library/Homebrew/formula.rb b/Library/Homebrew/formula.rb
index b4ac1c94922c2..a8d8be768bc35 100644
--- a/Library/Homebrew/formula.rb
+++ b/Library/Homebrew/formula.rb
@@ -42,6 +42,7 @@
 require "api"
 require "api_hashable"
 require "utils/output"
+require "pypi_packages"
 
 # A formula provides instructions and metadata for Homebrew to install a piece
 # of software. Every Homebrew formula is a {Formula}.
@@ -219,6 +220,11 @@ class Formula
   sig { returns(T.any(BuildOptions, Tab)) }
   attr_reader :build
 
+  # Information about PyPI mappings for this {Formula} is stored
+  # as {PypiPackages} object.
+  sig { returns(PypiPackages) }
+  attr_reader :pypi_packages_info
+
   # Whether this formula should be considered outdated
   # if the target of the alias it was installed with has since changed.
   # Defaults to true.
@@ -267,6 +273,9 @@ def initialize(name, path, spec, alias_path: nil, tap: nil, force_bottle: false)
       Tap.from_path(path)
     end
 
+    @pypi_packages_info = T.let(self.class.pypi_packages_info || PypiPackages.from_json_file(@tap, @name),
+                                PypiPackages)
+
     @full_name = T.let(T.must(full_name_with_optional_tap(name)), String)
     @full_alias_name = T.let(full_name_with_optional_tap(@alias_name), T.nilable(String))
 
@@ -3426,6 +3435,7 @@ def inherited(child)
           [phase, DEFAULT_NETWORK_ACCESS_ALLOWED]
         end, T.nilable(T::Hash[Symbol, T::Boolean]))
         @preserve_rpath = T.let(false, T.nilable(T::Boolean))
+        @pypi_packages_info = T.let(nil, T.nilable(PypiPackages))
       end
     end
 
@@ -3464,6 +3474,9 @@ def on_system_blocks_exist? = !!@on_system_blocks_exist
     sig { returns(T.nilable(KegOnlyReason)) }
     attr_reader :keg_only_reason
 
+    sig { returns(T.nilable(PypiPackages)) }
+    attr_reader :pypi_packages_info
+
     # A one-line description of the software. Used by users to get an overview
     # of the software and Homebrew maintainers.
     # Shows when running `brew info`.
@@ -3919,6 +3932,57 @@ def head(val = nil, specs = {}, &block)
       end
     end
 
+    # Adds information about PyPI formula mapping as {PypiPackages} object.
+    # It provides a way to specify package name in PyPI repository,
+    # define extra packages, or remove them (e.g. if formula installs them as a dependency).
+    #
+    # Examples of usage:
+    # ```rb
+    # # It will use information about the PyPI package `foo` to update resources
+    # pypi_packages package_name: "foo"
+    #
+    # Add "extra" packages and remove unneeded ones
+    # depends_on "numpy"
+    #
+    # pypi_packages extra_packages: "setuptools", exclude_packages: "numpy"
+    #
+    # # Special case: empty `package_name` allows to skip resource updates for non-extra packages
+    # pypi_packages package_name: "", extra_packages: "setuptools"
+    # ```
+    sig {
+      params(
+        package_name:        T.nilable(String),
+        extra_packages:      T.nilable(T.any(String, T::Array[String])),
+        exclude_packages:    T.nilable(T.any(String, T::Array[String])),
+        dependencies:        T.nilable(T.any(String, T::Array[String])),
+        needs_manual_update: T::Boolean,
+      ).void
+    }
+    def pypi_packages(
+      package_name: nil,
+      extra_packages: nil,
+      exclude_packages: nil,
+      dependencies: nil,
+      needs_manual_update: false
+    )
+      if needs_manual_update
+        @pypi_packages_info = PypiPackages.new needs_manual_update: true
+        return
+      end
+
+      if [package_name, extra_packages, exclude_packages, dependencies].all?(&:nil?)
+        raise ArgumentError, "must provide at least one argument"
+      end
+
+      # Sadly `v1, v2, v3 = [v1, v2, v3].map { |x| Array(x) }` does not work
+      # for typechecker
+      extra_packages = Array(extra_packages)
+      exclude_packages = Array(exclude_packages)
+      dependencies = Array(dependencies)
+
+      @pypi_packages_info = PypiPackages.new(package_name:, extra_packages:, exclude_packages:, dependencies:)
+    end
+
     # Additional downloads can be defined as {resource}s and accessed in the
     # install method. Resources can also be defined inside a {.stable} or
     # {.head} block. This mechanism replaces ad-hoc "subformula" classes.
diff --git a/Library/Homebrew/pypi_packages.rb b/Library/Homebrew/pypi_packages.rb
new file mode 100644
index 0000000000000..dbb0ce4192614
--- /dev/null
+++ b/Library/Homebrew/pypi_packages.rb
@@ -0,0 +1,71 @@
+# typed: strict
+# frozen_string_literal: true
+
+# Helper class for `pypi_packages` DSL.
+# @api internal
+class PypiPackages
+  sig { returns(T.nilable(String)) }
+  attr_reader :package_name
+
+  sig { returns(T::Array[String]) }
+  attr_reader :extra_packages
+
+  sig { returns(T::Array[String]) }
+  attr_reader :exclude_packages
+
+  sig { returns(T::Array[String]) }
+  attr_reader :dependencies
+
+  sig { params(tap: T.nilable(Tap), formula_name: String).returns(T.attached_class) }
+  def self.from_json_file(tap, formula_name)
+    list_entry = tap&.pypi_formula_mappings&.fetch(formula_name, nil)
+
+    return new(defined_pypi_mapping: false) if list_entry.nil?
+
+    case T.cast(list_entry, T.any(FalseClass, String, T::Hash[String, T.any(String, T::Array[String])]))
+    when false
+      new needs_manual_update: true
+    when String
+      new package_name: list_entry
+    when Hash
+      package_name = list_entry["package_name"]
+      extra_packages = list_entry.fetch("extra_packages", [])
+      exclude_packages = list_entry.fetch("exclude_packages", [])
+      dependencies = list_entry.fetch("dependencies", [])
+
+      new package_name:, extra_packages:, exclude_packages:, dependencies:
+    end
+  end
+
+  sig {
+    params(
+      package_name:         T.nilable(String),
+      extra_packages:       T::Array[String],
+      exclude_packages:     T::Array[String],
+      dependencies:         T::Array[String],
+      needs_manual_update:  T::Boolean,
+      defined_pypi_mapping: T::Boolean,
+    ).void
+  }
+  def initialize(
+    package_name: nil,
+    extra_packages: [],
+    exclude_packages: [],
+    dependencies: [],
+    needs_manual_update: false,
+    defined_pypi_mapping: true
+  )
+    @package_name = T.let(package_name, T.nilable(String))
+    @extra_packages = T.let(extra_packages, T::Array[String])
+    @exclude_packages = T.let(exclude_packages, T::Array[String])
+    @dependencies = T.let(dependencies, T::Array[String])
+    @needs_manual_update = T.let(needs_manual_update, T::Boolean)
+    @defined_pypi_mapping = T.let(defined_pypi_mapping, T::Boolean)
+  end
+
+  sig { returns(T::Boolean) }
+  def defined_pypi_mapping? = @defined_pypi_mapping
+
+  sig { returns(T::Boolean) }
+  def needs_manual_update? = @needs_manual_update
+end
diff --git a/Library/Homebrew/test/pypi_packages_spec.rb b/Library/Homebrew/test/pypi_packages_spec.rb
new file mode 100644
index 0000000000000..e28f7ff4e7d39
--- /dev/null
+++ b/Library/Homebrew/test/pypi_packages_spec.rb
@@ -0,0 +1,142 @@
+# frozen_string_literal: true
+
+require "pypi_packages"
+
+RSpec.describe PypiPackages do
+  describe ".from_json_file" do
+    let(:tap) { Tap.fetch("homebrew", "foo") }
+    let(:formula_name) { "test-formula" }
+    let(:mappings) { nil }
+
+    before do
+      allow(tap).to receive(:pypi_formula_mappings).and_return(mappings)
+    end
+
+    context "when JSON is `nil`" do
+      it "returns an instance with defined_pypi_mapping: false" do
+        pkgs = described_class.from_json_file(tap, formula_name)
+        expect(pkgs).to be_a(described_class)
+        expect(pkgs.defined_pypi_mapping?).to be(false)
+        expect(pkgs.needs_manual_update?).to be(false)
+        expect(pkgs.package_name).to be_nil
+      end
+    end
+
+    context "when JSON is an empty hash" do
+      let(:mappings) { {} }
+
+      it "returns an instance with defined_pypi_mapping: false" do
+        pkgs = described_class.from_json_file(tap, formula_name)
+        expect(pkgs).to be_a(described_class)
+        expect(pkgs.defined_pypi_mapping?).to be(false)
+        expect(pkgs.needs_manual_update?).to be(false)
+        expect(pkgs.package_name).to be_nil
+      end
+    end
+
+    context "when mapping entry is `false`" do
+      let(:mappings) { { formula_name => false } }
+
+      it "returns an instance with needs_manual_update: true" do
+        pkgs = described_class.from_json_file(tap, formula_name)
+        expect(pkgs).to be_a(described_class)
+        expect(pkgs.defined_pypi_mapping?).to be(true)
+        expect(pkgs.needs_manual_update?).to be(true)
+        expect(pkgs.package_name).to be_nil
+      end
+    end
+
+    context "when mapping entry is a String" do
+      let(:mappings) { { formula_name => "bar" } }
+
+      it "returns an instance with package_name set" do
+        pkgs = described_class.from_json_file(tap, formula_name)
+        expect(pkgs.package_name).to eq("bar")
+        expect(pkgs.extra_packages).to eq([])
+        expect(pkgs.exclude_packages).to eq([])
+        expect(pkgs.dependencies).to eq([])
+        expect(pkgs.defined_pypi_mapping?).to be(true)
+        expect(pkgs.needs_manual_update?).to be(false)
+      end
+    end
+
+    context "when mapping entry is `true`" do
+      let(:mappings) { { formula_name => true } }
+
+      it "raises a Sorbet type error" do
+        expect do
+          described_class.from_json_file(tap, formula_name)
+        end.to raise_error(TypeError, /got type TrueClass/)
+      end
+    end
+
+    context "when mapping entry is a Hash" do
+      let(:mappings) do
+        {
+          formula_name => {
+            "package_name"     => "bar",
+            "extra_packages"   => ["baz"],
+            "exclude_packages" => ["qux"],
+            "dependencies"     => ["quux"],
+          },
+        }
+      end
+
+      it "returns an instance with all fields populated" do
+        pkgs = described_class.from_json_file(tap, formula_name)
+        expect(pkgs.package_name).to eq("bar")
+        expect(pkgs.extra_packages).to eq(["baz"])
+        expect(pkgs.exclude_packages).to eq(["qux"])
+        expect(pkgs.dependencies).to eq(["quux"])
+        expect(pkgs.defined_pypi_mapping?).to be(true)
+        expect(pkgs.needs_manual_update?).to be(false)
+      end
+    end
+
+    context "when mapping entry hash omits optional keys" do
+      let(:mappings) do
+        { formula_name => { "package_name" => "bar" } }
+      end
+
+      it "fills missing keys with empty arrays" do
+        pkgs = described_class.from_json_file(tap, formula_name)
+        expect(pkgs.package_name).to eq("bar")
+        expect(pkgs.extra_packages).to eq([])
+        expect(pkgs.exclude_packages).to eq([])
+        expect(pkgs.dependencies).to eq([])
+      end
+    end
+
+    context "when mapping entry hash uses Array for `package_name`" do
+      let(:mappings) do
+        { formula_name => { "package_name" => ["bar"] } }
+      end
+
+      it "raises a Sorbet type error" do
+        expect do
+          described_class.from_json_file(tap, formula_name)
+        end.to raise_error(TypeError, /got type Array/)
+      end
+    end
+
+    context "when mapping entry hash uses String for keys" do
+      let(:mappings) do
+        { formula_name => { "extra_packages" => "bar" } }
+      end
+
+      it "raises a Sorbet type error" do
+        expect do
+          described_class.from_json_file(tap, formula_name)
+        end.to raise_error(TypeError, /got type String/)
+      end
+    end
+
+    context "when tap is `nil`" do
+      it "fills missing keys with empty arrays" do
+        pkgs = described_class.from_json_file(nil, formula_name)
+        expect(pkgs.defined_pypi_mapping?).to be(false)
+        expect(pkgs.package_name).to be_nil
+      end
+    end
+  end
+end
diff --git a/Library/Homebrew/utils/pypi.rb b/Library/Homebrew/utils/pypi.rb
index fcf8f839ddf60..f898154d3bbde 100644
--- a/Library/Homebrew/utils/pypi.rb
+++ b/Library/Homebrew/utils/pypi.rb
@@ -237,23 +237,16 @@ def self.update_python_resources!(formula, version: nil, package_name: nil, extr
                                     exclude_packages: nil, dependencies: nil, install_dependencies: false,
                                     print_only: false, silent: false, verbose: false,
                                     ignore_errors: false, ignore_non_pypi_packages: false)
-    auto_update_list = formula.tap&.pypi_formula_mappings
-    if auto_update_list.present? && auto_update_list.key?(formula.full_name) &&
-       package_name.blank? && extra_packages.blank? && exclude_packages.blank?
-
-      list_entry = auto_update_list[formula.full_name]
-      case list_entry
-      when false
-        unless print_only
-          odie "The resources for \"#{formula.name}\" need special attention. Please update them manually."
-        end
-      when String
-        package_name = list_entry
-      when Hash
-        package_name = list_entry["package_name"]
-        extra_packages = list_entry["extra_packages"]
-        exclude_packages = list_entry["exclude_packages"]
-        dependencies = list_entry["dependencies"]
+    list_entry = formula.pypi_packages_info
+    if list_entry.defined_pypi_mapping? && package_name.blank? && extra_packages.blank? && exclude_packages.blank?
+
+      if list_entry.needs_manual_update? && !print_only
+        odie "The resources for \"#{formula.name}\" need special attention. Please update them manually."
+      else
+        package_name = list_entry.package_name
+        extra_packages = list_entry.extra_packages
+        exclude_packages = list_entry.exclude_packages
+        dependencies = list_entry.dependencies
       end
     end