The initial results from the unit tests of the code collection show that there is a large influence of the used fitting algorithm on IVIM parameter calculations, which contributes to the poor reproducibility in literature. In addition, many centers use in-house developed algorithms making it difficult to reproduce results. In the current project, we are performing an in depth analysis of all algorithms to study how large the influence of fitting algorithms is on the calculated IVIM parameters. With these results we can estimate the reproducibility of IVIM parameter calculations and propose recommendations on analysis details, like fitting bounds and initial guesses.
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