diff --git a/src/relax/op/tensor/index.cc b/src/relax/op/tensor/index.cc
index 29bf767f9542..b346b6681b03 100644
--- a/src/relax/op/tensor/index.cc
+++ b/src/relax/op/tensor/index.cc
@@ -549,7 +549,23 @@ StructInfo InferStructInfoDynStridedSlice(const Call& call, const BlockBuilder&
   return TensorStructInfo(data_sinfo->dtype, n_axis, data_sinfo->vdevice);
 }
 
-// TODO(tvm-team): Register FRelaxInferLayout, TMixedPrecisionPolicy
+InferLayoutOutput InferLayoutDynStridedSlice(
+    const Call& call, const ffi::Map<ffi::String, ffi::Array<ffi::String>>& desired_layouts,
+    const VarLayoutMap& var_layout_map) {
+  ICHECK(NoDesiredLayout(call, desired_layouts));
+
+  const auto* tensor_sinfo = GetStructInfoAs<TensorStructInfoNode>(call->args[0]);
+  CHECK(tensor_sinfo) << "Invalid Call";
+  CHECK(!tensor_sinfo->IsUnknownNdim()) << "Layout inference only supports known dimensionality, "
+                                        << "but expression " << call << " has argument "
+                                        << call->args[0] << " of unknown dimensionality.";
+  int ndim = tensor_sinfo->ndim;
+  // Since begin/end/strides are dynamic tensors, we cannot transform
+  // them at compile time. Fall back to the initial layout.
+  LayoutDecision initial = LayoutDecision(InitialLayout(ndim));
+  return InferLayoutOutput({initial}, {initial}, Attrs());
+}
+
 TVM_REGISTER_OP("relax.dynamic_strided_slice")
     .set_num_inputs(4)
     .add_argument("x", "Tensor", "The source tensor to be sliced.")
@@ -557,6 +573,8 @@ TVM_REGISTER_OP("relax.dynamic_strided_slice")
     .add_argument("end", "Tensor", "Indices indicating end of the slice.")
     .add_argument("strides", "Tensor", "The stride values.")
     .set_attr<FInferStructInfo>("FInferStructInfo", InferStructInfoDynStridedSlice)
+    .set_attr<FRelaxInferLayout>("FRelaxInferLayout", InferLayoutDynStridedSlice)
+    .set_attr<TMixedPrecisionPolicy>("TMixedPrecisionPolicy", MixedPrecisionPolicyKind::kFollow)
     .set_attr<Bool>("FPurity", Bool(true));
 
 }  // namespace relax
diff --git a/tests/python/relax/test_transform_convert_layout.py b/tests/python/relax/test_transform_convert_layout.py
index 42e1cff284b1..5ba0c4d86771 100644
--- a/tests/python/relax/test_transform_convert_layout.py
+++ b/tests/python/relax/test_transform_convert_layout.py
@@ -5231,5 +5231,57 @@ def main(
     verify(Input, Expected)
 
 
+def test_conv2d_dynamic_strided_slice():
+    @I.ir_module
+    class Input:
+        @R.function
+        def main(
+            x: R.Tensor((2, 3, 28, 28), "float32"),
+            w: R.Tensor((4, 3, 3, 3), "float32"),
+            begin: R.Tensor((4,), "int64"),
+            end: R.Tensor((4,), "int64"),
+            strides: R.Tensor((4,), "int64"),
+        ) -> R.Tensor(None, "float32", ndim=4):
+            with R.dataflow():
+                gv: R.Tensor((2, 4, 26, 26), "float32") = R.nn.conv2d(x, w, out_dtype="float32")
+                gv2 = R.dynamic_strided_slice(gv, begin, end, strides)
+                R.output(gv2)
+            return gv2
+
+    @I.ir_module
+    class Expected:
+        @R.function
+        def main(
+            x: R.Tensor((2, 3, 28, 28), dtype="float32"),
+            w: R.Tensor((4, 3, 3, 3), dtype="float32"),
+            begin: R.Tensor((4,), dtype="int64"),
+            end: R.Tensor((4,), dtype="int64"),
+            strides: R.Tensor((4,), dtype="int64"),
+        ) -> R.Tensor(None, dtype="float32", ndim=4):
+            with R.dataflow():
+                lv: R.Tensor((2, 28, 28, 3), dtype="float32") = R.permute_dims(x, axes=[0, 2, 3, 1])
+                lv1: R.Tensor((4, 3, 3, 3), dtype="float32") = R.permute_dims(w, axes=[0, 2, 3, 1])
+                gv: R.Tensor((2, 26, 26, 4), dtype="float32") = R.nn.conv2d(
+                    lv,
+                    lv1,
+                    strides=[1, 1],
+                    padding=[0, 0, 0, 0],
+                    dilation=[1, 1],
+                    groups=1,
+                    data_layout="NHWC",
+                    kernel_layout="OHWI",
+                    out_layout="NHWC",
+                    out_dtype="float32",
+                )
+                lv2: R.Tensor((2, 4, 26, 26), dtype="float32") = R.permute_dims(
+                    gv, axes=[0, 3, 1, 2]
+                )
+                gv2 = R.dynamic_strided_slice(lv2, begin, end, strides)
+                R.output(gv2)
+            return gv2
+
+    verify(Input, Expected)
+
+
 if __name__ == "__main__":
     tvm.testing.main()
diff --git a/tests/python/relax/test_transform_to_mixed_precision.py b/tests/python/relax/test_transform_to_mixed_precision.py
index 4e90216f9bc0..2a23890d7f62 100644
--- a/tests/python/relax/test_transform_to_mixed_precision.py
+++ b/tests/python/relax/test_transform_to_mixed_precision.py
@@ -1064,5 +1064,58 @@ def tir_identity(
     tvm.ir.assert_structural_equal(Expected, After)
 
 
+def test_dynamic_strided_slice():
+    @I.ir_module
+    class Input:
+        @R.function
+        def main(
+            x: R.Tensor((2, 3, 28, 28), "float32"),
+            w: R.Tensor((4, 3, 3, 3), "float32"),
+            begin: R.Tensor((4,), "int64"),
+            end: R.Tensor((4,), "int64"),
+            strides: R.Tensor((4,), "int64"),
+        ) -> R.Tensor(None, "float32", ndim=4):
+            with R.dataflow():
+                lv: R.Tensor((2, 4, 26, 26), "float32") = R.nn.conv2d(x, w, out_dtype="float32")
+                gv = R.dynamic_strided_slice(lv, begin, end, strides)
+                R.output(gv)
+            return gv
+
+    @I.ir_module
+    class Expected:
+        @R.function
+        def main(
+            x: R.Tensor((2, 3, 28, 28), dtype="float32"),
+            w: R.Tensor((4, 3, 3, 3), dtype="float32"),
+            begin: R.Tensor((4,), dtype="int64"),
+            end: R.Tensor((4,), dtype="int64"),
+            strides: R.Tensor((4,), dtype="int64"),
+        ) -> R.Tensor(None, dtype="float32", ndim=4):
+            with R.dataflow():
+                lv: R.Tensor((2, 3, 28, 28), dtype="float16") = R.astype(x, dtype="float16")
+                lv1: R.Tensor((4, 3, 3, 3), dtype="float16") = R.astype(w, dtype="float16")
+                lv2: R.Tensor((2, 4, 26, 26), dtype="float32") = R.nn.conv2d(
+                    lv,
+                    lv1,
+                    strides=[1, 1],
+                    padding=[0, 0, 0, 0],
+                    dilation=[1, 1],
+                    groups=1,
+                    data_layout="NCHW",
+                    kernel_layout="OIHW",
+                    out_layout="NCHW",
+                    out_dtype="float32",
+                )
+                lv3: R.Tensor((2, 4, 26, 26), dtype="float16") = R.astype(lv2, dtype="float16")
+                lv4: R.Tensor((2, 4, 26, 26), dtype="float32") = R.astype(lv3, dtype="float32")
+                gv: R.Tensor(None, dtype="float32", ndim=4) = R.dynamic_strided_slice(
+                    lv4, begin, end, strides
+                )
+                R.output(gv)
+            return gv
+
+    _assert_test(Input, Expected)
+
+
 if __name__ == "__main__":
     tvm.testing.main()