Hello Elisha,
on Linux with Wine, this game looses Keyboard and mouse after Alt+Tab, even when I launch game with FullWIndowedMode option.
I limited fps to 29 fps because this game have issues at higher framerate.
I joined you my dxwrapper ini and log, tell me if you think dxwrapper can avoid this game to loose keyboard and mouse after an Alt-Tab.
Spider-Man.zip