diff --git a/pyogrio/__init__.py b/pyogrio/__init__.py
index 17db8339..9e871d10 100644
--- a/pyogrio/__init__.py
+++ b/pyogrio/__init__.py
@@ -23,6 +23,7 @@
     read_bounds,
     read_info,
     set_gdal_config_options,
+    vsi_curl_clear_cache,
     vsi_listtree,
     vsi_rmtree,
     vsi_unlink,
@@ -49,6 +50,7 @@
     "read_dataframe",
     "read_info",
     "set_gdal_config_options",
+    "vsi_curl_clear_cache",
     "vsi_listtree",
     "vsi_rmtree",
     "vsi_unlink",
diff --git a/pyogrio/_ogr.pxd b/pyogrio/_ogr.pxd
index 24dfa817..9ca6a52b 100644
--- a/pyogrio/_ogr.pxd
+++ b/pyogrio/_ogr.pxd
@@ -63,6 +63,8 @@ cdef extern from "cpl_vsi.h" nogil:
     int         VSIFCloseL(VSILFILE *fp)
     int         VSIFFlushL(VSILFILE *fp)
     int         VSIUnlink(const char *path)
+    void        VSICurlPartialClearCache(const char *prefix)
+    void        VSICurlClearCache()
 
     VSILFILE*       VSIFileFromMemBuffer(const char *path,
                                          void *data,
diff --git a/pyogrio/_vsi.pyx b/pyogrio/_vsi.pyx
index 5cc7fb38..34188b60 100644
--- a/pyogrio/_vsi.pyx
+++ b/pyogrio/_vsi.pyx
@@ -286,3 +286,31 @@ def ogr_vsi_unlink(str path):
     errcode = VSIUnlink(path_c)
     if errcode != 0:
         raise OSError(f"Error removing '{path}': {errcode=}")
+
+
+def ogr_vsi_curl_clear_all_cache():
+    """Clean local cache associated with /vsicurl/.
+
+    """
+
+    VSICurlClearCache()
+
+
+def ogr_vsi_curl_clear_cache(str prefix):
+    """Clean local cache associated with /vsicurl/.
+
+    Parameters
+    ----------
+    prefix : str
+        Filename or prefix to clear associated cache.
+
+    """
+    cdef const char *prefix_c
+
+    try:
+        prefix_b = prefix.encode("UTF-8")
+    except UnicodeDecodeError:
+        prefix_b = prefix
+    prefix_c = prefix_b
+
+    VSICurlPartialClearCache(prefix_c)
diff --git a/pyogrio/core.py b/pyogrio/core.py
index 4e0fe3c1..7e7706e3 100644
--- a/pyogrio/core.py
+++ b/pyogrio/core.py
@@ -7,6 +7,7 @@
     _mask_to_wkb,
     _preprocess_options_key_value,
     get_vsi_path_or_buffer,
+    vsi_path,
 )
 
 with GDALEnv():
@@ -26,6 +27,8 @@
         set_gdal_config_options as _set_gdal_config_options,
     )
     from pyogrio._vsi import (
+        ogr_vsi_curl_clear_all_cache,
+        ogr_vsi_curl_clear_cache,
         ogr_vsi_listtree,
         ogr_vsi_rmtree,
         ogr_vsi_unlink,
@@ -385,3 +388,19 @@ def vsi_unlink(path: str | Path):
         path = path.as_posix()
 
     ogr_vsi_unlink(path)
+
+
+def vsi_curl_clear_cache(prefix: str = ""):
+    """Clean local cache associated with /vsicurl/.
+
+    Parameters
+    ----------
+    prefix : str
+        Filename or prefix to clear associated cache. If not specified clear all cache.
+
+    """
+    if prefix == "":
+        ogr_vsi_curl_clear_all_cache()
+    else:
+        vsi_prefix = vsi_path(prefix)
+        ogr_vsi_curl_clear_cache(vsi_prefix)
diff --git a/pyogrio/tests/test_core.py b/pyogrio/tests/test_core.py
index 634cbc1c..fbce5afd 100644
--- a/pyogrio/tests/test_core.py
+++ b/pyogrio/tests/test_core.py
@@ -14,6 +14,7 @@
     read_bounds,
     read_info,
     set_gdal_config_options,
+    vsi_curl_clear_cache,
     vsi_listtree,
     vsi_rmtree,
     vsi_unlink,
@@ -700,3 +701,13 @@ def test_vsimem_unlink_error(naturalearth_lowres_vsimem):
 
     with pytest.raises(FileNotFoundError, match="Path does not exist"):
         vsi_unlink("/vsimem/non-existent.gpkg")
+
+
+def test_vsi_curl_clear_cache_empty_default():
+    # Validate call doesn't raise any error when no prefix is used
+    vsi_curl_clear_cache()
+
+
+def test_vsi_curl_clear_cache():
+    # Validate call doesn't raise any error when prefix/path is used
+    vsi_curl_clear_cache("http://example.com/prefix")