diff --git a/Cargo.toml b/Cargo.toml
index bc58737..c44beed 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -36,7 +36,7 @@ libc = "0.2"
 needletail = { version = "0.6", optional = true, default-features = false}
 
 minimap2-sys = { path = "./minimap2-sys", version = "0.1.24+minimap2.2.30" }
-rust-htslib = { version = "0.50", default-features = false, optional = true }
+rust-htslib = { version = "0.51", default-features = false, optional = true }
 
 [dev-dependencies]
 rayon = "1.10"