diff --git a/llvm/CMakeLists.txt b/llvm/CMakeLists.txt
index ed44b16bf9aeb..6015b5ccc868e 100644
--- a/llvm/CMakeLists.txt
+++ b/llvm/CMakeLists.txt
@@ -289,6 +289,14 @@ if(LLVM_CCACHE_BUILD)
     set(LLVM_CCACHE_PARAMS "CCACHE_CPP2=yes CCACHE_HASHDIR=yes CCACHE_SLOPPINESS=pch_defines,time_macros"
         CACHE STRING "Parameters to pass through to ccache")
 
+    # FIXME: This is a workaround for an unknown underlying issue where the header file
+    # changes but then the pch does not get rebuilt before its dependencies.
+    # See: https://github.com/llvm/llvm-project/issues/142449
+    set(LLVM_CCACHE_PCH OFF CACHE BOOL "Use precompiled headers in ccache builds")
+    if (NOT LLVM_CCACHE_PCH)
+      set(CMAKE_DISABLE_PRECOMPILE_HEADERS "ON")
+    endif()
+
     if(NOT CMAKE_HOST_WIN32)
       set(CCACHE_PROGRAM "${LLVM_CCACHE_PARAMS} ${CCACHE_PROGRAM}")
       if (LLVM_CCACHE_MAXSIZE)
diff --git a/llvm/docs/CMake.rst b/llvm/docs/CMake.rst
index 674e4969c6912..5828bfeff6d7e 100644
--- a/llvm/docs/CMake.rst
+++ b/llvm/docs/CMake.rst
@@ -412,7 +412,9 @@ enabled sub-projects. Nearly all of these variable names begin with
   Defaults to OFF.  The size and location of the cache maintained
   by ``ccache`` can be adjusted via the LLVM_CCACHE_MAXSIZE and LLVM_CCACHE_DIR
   options, which are passed to the CCACHE_MAXSIZE and CCACHE_DIR environment
-  variables, respectively.
+  variables, respectively. By default, enabling the ccache build will disable
+  using precompiled headers as they have been known to cause intermittent CI
+  failures. This can be adjusted via the LLVM_CCACHE_PCH option.
 
 **LLVM_CODE_COVERAGE_TARGETS**:STRING
   If set to a semicolon separated list of targets, those targets will be used