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<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" >
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<title>Slavov Lab | Welcome new members</title>
<meta name="description" content="Introduction, resources and logistics for new team members of the Slavov Laboratory | Research on post-transcriptional regulation mediated by ribosome specialization. Developing and applying methods for single cell proteomics by mass spectrometry" />
<title itemprop='name'>Slavov Lab</title>
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<a href="https://slavovlab.net" title="Slavov lab | Quantitative Systems Biology" rel="home" target="_blank" >
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<a href="https://slavovlab.net" title="Slavov Lab | Quantitative Systems Biology" rel="home">Slavov Laboratory | Quantitative Biology</a>
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Seeking principles
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in the coordination among protein synthesis, metabolism, cell growth and differentiation
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<!-- <div style="font-size:25px; line-height:65px;" >Publications</div> -->
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<a href="index.html" >Home</a> |
<a href="publications.htm">Publications</a> |
<a href="research.htm">Research</a> |
<a href="people.htm" id="active" >People</a> |
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<div style="font-family: 'Josefin Slab', serif; Font-Size: 48px; letter-spacing: 2.5px;" >
Welcome
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<div style="Font-Size: 16px; line-height:24px; letter-spacing: 1.4px; text-align: left; text-justify: none;">
This welcome page outlines the <a href="#Goals">goals</a> and the logistical <a href="#Organization">organization</a> of the Slavov Laboratory.
It also provides links to accessible <a href="#Introduction">introductory resources</a> for scientific topics and technologies relevant to our research.
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<div class="HeadingStyle" style="Font-Size:30px; letter-spacing: 2px;" id="Goals" >Goals</div>
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<li> Help each lab member to grow as a scientist / engineer and become more independent
<li> Learn to prioritize, to focus on the essential and ignore distractions
<li> Learn to formulate and test hypotheses
<li> Develop new skills
<li> Make discoveries and develop methods that are conceptually original, distinctive & <a href="https://blog.slavovlab.net/2013/09/26/the-best-projects-are-least-obvious/">non-redundant</a>.
<li> Publish papers, advance our careers and raise support for the goals above.
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<div class="HeadingStyle" style="Font-Size:30px; letter-spacing: 2px;" id="Organization" >Organization</div>
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<li> <strong>Scheduling</strong>
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<li>All scheduling is done via the lab google calendar that will be shared with you.
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<li> <strong>Data Sharing & Communication</strong>
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<li>We also communicate via lab slack account.
<li>We share data and collaborate on manuscripts via google drive, overleaf, and google docs
<li>The slides for all lab presentations have to be placed in the designated google drive folder.
<li>We have a local server and a google account for data storage.
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<h2 class="HeadingStyle" style="Font-Size: 24px; letter-spacing: 2px;" >Meetings</h2>
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<li> <strong>Weekly group meeting</strong>
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<li>Summarize results from the last 1-2 months or lead a journal club discussion. The goal is to present your results more holistically in perspective. We rotate alphabetically according to the order from our <a href="people.htm">website</a>.
<li>Get feedback from everybody and practice your presentation skills.
</ul>
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<li> <strong>Weekly club meetings</strong>
<ul type="square" style="line-height: 150%" >
<li>Design experiments, set goals, get help with data analysis and interpretation
<li>Present less mature results to colleagues who need little background
<li>Update on goals set the previous week / month.
<li> To stay focused and organized, we follow <b>Focus 20/20</b>:
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<li> Start with the central point / goal of the presented work
<li> Presentations are up to 20 min max.
</ul>
</ul>
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<li> <strong>General Meeting Time (GMT)</strong>
<ul type="square" style="line-height: 150%" >
<li>Questions of limited interest for the rest of the group
<li>Detailed feedback on manuscripts, career development, et al.
<li>If you want a 1-1 meeting, book a slot within the GMT period.
</ul>
</ul>
The meetings do not have to take the full allotted time.
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<div class="HeadingStyle" style="Font-Size:30px; letter-spacing: 2px;" id="Introduction" >Introductory resources</div>
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<div class="HeadingStyle" style="Font-Size:20px; letter-spacing: 2px;" >Mass spectrometry</div>
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<li> <strong>Videos</strong>
<ul type="square" style="line-height: 150%" >
<li><a href="https://youtu.be/XNyYZ8w_8jY" target="_blank">Introduction to mass spectrometry experiments and their optimization</a> by Gray Huffman
<li>A basic into to <a href="https://youtu.be/jzcwOC3Y_ZE?si=2NIAQiGa9mbm5gI2" target="_blank">proteomic identification through database search</a> by David Tabb
<li><a href="https://www.youtube.com/watch?v=P0-_gDUNikc" target="_blank">Introduction to mass spectrometry</a> by Harrison Specht
<li><a href="https://slavovlab.net/teaching/Methods-of-Bioengineering.html" target="_blank">Introduction to mass spectrometry</a> by Nikolai Slavov
<li><a href="https://youtu.be/1t0jugs2lcs" alt="Primer on single-cell proteomics by mass spectrometry | Prof. Nikolai Slavov | SCP2022" target="_blank">Primer on single-cell proteomics by mass spectrometry</a> by Nikolai Slavov
<li><a href="https://youtu.be/5r7COOvbVfE" title="Research talk focussing on sigle-cell biology at the 6th Annual Single-cell proteomics conference" target="_blank">Biological and technological frontiers for single-cell proteomics</a>
</ul>
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<li> <strong>Review Articles</strong>
<ul type="square" style="line-height: 150%" >
<li>Computational methods for understanding mass spec data: <a href="Slavov-Lab-Publications/Protocols/MS_Intro/Pavel_Cox_2018.pdf" target="_blank" title="Computational methods for understanding mass spec data">Sinitcyn, Cox et al., 2018</a>
<li>Protein Analysis by mass spec [small book]: <a href="Slavov-Lab-Publications/Protocols/MS_Intro/Yates-Review.pdf" target="_blank" title="Protein Analysis by mass spec">Yates et al., 2013</a>
<li>Single-cell protein analysis by mass spectrometry: <a href="Slavov-Lab-Publications/2020_Single-cell_protein_analysis_by_mass-spectrometry_Current_Opinion.pdf" target="_blank" title="Single-cell protein analysis by mass spectrometry">Slavov, 2020</a>
<li>Single-Cell Proteomic Technologies: Tools in the quest for principles: <a href="https://www.annualreviews.org/content/journals/10.1146/annurev-biophys-021424-011450" target="_blank">Slavov, 2026</a>, <a href="Slavov-Lab-Publications/2026_Single-Cell-Proteomic-Technologies-Review.pdf" target="_blank">PDF</a>
</ul>
<br>
<li> <strong>Perspective Articles</strong>
<ul type="square" style="line-height: 150%" >
<li><a href="Slavov-Lab-Publications/2022_plexDIA_Framework_NatureBiotech.pdf" target="_blank" >Framework for multiplicative scaling of single-cell proteomics</a>, <i>Nature Biotechnol</i>
<li><a href="Slavov-Lab-Publications/2021_driving_single_cell_proteomics_forward_with_innovation.pdf" target="_blank">Advancing single-cell proteomics</a>, <i>JPR</i> Perspective
<li><a href="Slavov-Lab-Publications/2020_Slavov_Science_Single-cell-mass-spec.pdf" target="_blank">Single-cell proteomics</a>, <i>Science</i> Perspective
</ul>
<li> <strong>Courses:</strong> Lectures and problems from past courses are available from our <a href="teaching/index.html" target="_blank">teaching</a> pages.
</ul>
<br><br>
<div class="HeadingStyle" style="Font-Size:20px; letter-spacing: 2px;" >Regulation of protein synthsis and degradation</div>
<ul type="circle" style="line-height: 150%" >
<li> <strong>Videos</strong>
<ul type="square" style="line-height: 150%" >
<li><a href="https://youtu.be/LN4UWvnlmng" target="_blank">Alternative translation</a> <br>
<li><a href="https://youtu.be/VQ5ehxl-u8k" target="_blank">Differential stoichiometry among core ribosomal proteins</a> <br>
</ul>
<br>
<li> <strong>Review Papers</strong>
<ul type="square" style="line-height: 150%" >
<a href="Slavov-Lab-Publications/2019_Emmott_Slavov_Ribosome-Specialization_TIBS.pdf" target="_blank">Ribosome Stoichiometry: From Form to Function (Emmott Jovanovic & Slavov, 2018)</a>
</ul>
</ul>
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<div class="Copyright">Copyright © <a href="https://coe.northeastern.edu/people/slavov-nikolai/" target="_blank">Nikolai Slavov</a></div>
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