diff --git a/changelog/1221.feature.rst b/changelog/1221.feature.rst
new file mode 100644
index 000000000..0b7b9c949
--- /dev/null
+++ b/changelog/1221.feature.rst
@@ -0,0 +1 @@
+have ``--skip-existing`` option work with newer versions of ``Nexus Repository OSS``.
\ No newline at end of file
diff --git a/tests/test_upload.py b/tests/test_upload.py
index 249163999..59f01dc93 100644
--- a/tests/test_upload.py
+++ b/tests/test_upload.py
@@ -466,7 +466,7 @@ def test_prints_skip_message_for_response(
                     "http://www.foo.bar"
                 ),
             ),
-            id="nexus",
+            id="nexus_old_case1",
         ),
         pytest.param(
             dict(
@@ -477,6 +477,18 @@ def test_prints_skip_message_for_response(
                     "</div>\n"
                 ),
             ),
+            id="nexus_old_case2",
+        ),
+        pytest.param(
+            dict(
+                status_code=400,
+                text=(
+                    '<div class="content-section">\n'
+                    "    pypi-local:twine/1.5.0/twine-1.5.0-py2.py3-none-any.whl "
+                    "cannot be updated"
+                    "</div>\n"
+                ),
+            ),
             id="nexus_new",
         ),
         pytest.param(
diff --git a/twine/commands/upload.py b/twine/commands/upload.py
index 939e1dfab..beb81ab38 100644
--- a/twine/commands/upload.py
+++ b/twine/commands/upload.py
@@ -62,7 +62,13 @@ def skip_upload(
         # PyPI / TestPyPI / GCP Artifact Registry
         or (status == 400 and any("already exist" in x for x in [reason, text]))
         # Nexus Repository OSS (https://www.sonatype.com/nexus-repository-oss)
-        or (status == 400 and any("updating asset" in x for x in [reason, text]))
+        or (
+            status == 400
+            and (
+                any("updating asset" in x for x in [reason, text])
+                or ("cannot be updated" in text)
+            )
+        )
         # Artifactory (https://jfrog.com/artifactory/)
         or (status == 403 and "overwrite artifact" in text)
         # Gitlab Enterprise Edition (https://about.gitlab.com)