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@article {Moses2025.02.24.640007,
author = {Moses, Lambda and Huseynov, Alik and Rich, Joseph M and Pachter, Lior},
title = {Geospatially informed representation of spatial genomics data with SpatialFeatureExperiment},
elocation-id = {2025.02.24.640007},
year = {2025},
doi = {10.1101/2025.02.24.640007},
publisher = {Cold Spring Harbor Laboratory},
abstract = {SpatialFeatureExperiment is a Bioconductor package that leverages the versatility of Simple Features for spatial data analysis and SpatialExperiment for single-cell -omics to provide an expansive and convenient S4 class for working with spatial -omics data.SpatialFeatureExperiment can be used to store and analyze a variety of spatial -omics data types, including data from the Visium, Xenium, MERFISH, SeqFish, and Slide-seq platforms, bringing spatial operations to the SingleCellExperiment ecosystem.Competing Interest StatementThe authors have declared no competing interest.},
URL = {https://www.biorxiv.org/content/early/2025/02/27/2025.02.24.640007},
eprint = {https://www.biorxiv.org/content/early/2025/02/27/2025.02.24.640007.full.pdf},
journal = {bioRxiv}
}
@article{rao2021exploring,
title={Exploring tissue architecture using spatial transcriptomics},
author={Rao, Anjali and Barkley, Dalia and Fran{\c{c}}a, Gustavo S and Yanai, Itai},
journal={Nature},
volume={596},
number={7871},
pages={211--220},
year={2021},
publisher={Nature Publishing Group UK London}
}
@article{emons2025harnessing,
title={Harnessing the potential of spatial statistics for spatial omics data with pasta},
author={Emons, Martin and Gunz, Samuel and Crowell, Helena L and Mallona, Izaskun and Kuehl, Malte and Furrer, Reinhard and Robinson, Mark D},
journal={Nucleic Acids Research},
volume={53},
number={17},
pages={gkaf870},
year={2025},
publisher={Oxford University Press}
}
@article{moses2023voyager,
title={Voyager: exploratory single-cell genomics data analysis with geospatial statistics},
author={Moses, Lambda and Einarsson, P{\'e}tur Helgi and Jackson, Kayla and Luebbert, Laura and Booeshaghi, A Sina and Antonsson, Sindri and Bray, Nicolas and Melsted, P{\'a}ll and Pachter, Lior},
journal={BioRxiv},
year={2023}
}
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title={Local indicators of spatial association—LISA},
author={Anselin, Luc},
journal={Geographical analysis},
volume={27},
number={2},
pages={93--115},
year={1995},
publisher={Wiley Online Library}
}
@incollection{anselin2019moran,
title={The Moran scatterplot as an ESDA tool to assess local instability in spatial association},
author={Anselin, Luc},
booktitle={Spatial analytical perspectives on GIS},
pages={111--126},
year={2019},
publisher={Routledge}
}
@article{moran1950notes,
title={Notes on continuous stochastic phenomena},
author={Moran, Patrick AP},
journal={Biometrika},
volume={37},
number={1/2},
pages={17--23},
year={1950},
publisher={JSTOR}
}
@article{yan2025svg,
title={Categorization of 34 computational methods to detect spatially variable genes from spatially resolved transcriptomics data},
author={Yan, Guanao and Hua, Shuo Harper and Li, Jingyi Jessica},
journal={Nature Communications},
volume={16},
number={1},
pages={1141},
year={2025},
publisher={Nature Publishing Group UK London}
}
@article{weber2023nnsvg,
title={nnSVG for the scalable identification of spatially variable genes using nearest-neighbor Gaussian processes},
author={Weber, Lukas M and Saha, Arkajyoti and Datta, Abhirup and Hansen, Kasper D and Hicks, Stephanie C},
journal={Nature communications},
volume={14},
number={1},
pages={4059},
year={2023},
publisher={Nature Publishing Group UK London}
}
@article{cai2024despace,
title={DESpace: spatially variable gene detection via differential expression testing of spatial clusters},
author={Cai, Peiying and Robinson, Mark D and Tiberi, Simone},
journal={Bioinformatics},
volume={40},
number={2},
pages={btae027},
year={2024},
publisher={Oxford University Press}
}
@article{aibar2017scenic,
title={SCENIC: single-cell regulatory network inference and clustering},
author={Aibar, Sara and Gonz{\'a}lez-Blas, Carmen Bravo and Moerman, Thomas and Huynh-Thu, V{\^a}n Anh and Imrichova, Hana and Hulselmans, Gert and Rambow, Florian and Marine, Jean-Christophe and Geurts, Pierre and Aerts, Jan and others},
journal={Nature methods},
volume={14},
number={11},
pages={1083--1086},
year={2017},
publisher={Nature Publishing Group US New York}
}
@article{aran2019reference,
title={Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage},
author={Aran, Dvir and Looney, Agnieszka P and Liu, Leqian and Wu, Esther and Fong, Valerie and Hsu, Austin and Chak, Suzanna and Naikawadi, Ram P and Wolters, Paul J and Abate, Adam R and others},
journal={Nature immunology},
volume={20},
number={2},
pages={163--172},
year={2019},
publisher={Nature Publishing Group US New York}
}
@book{baddeley2016spatial,
title={Spatial point patterns: methodology and applications with R},
author={Baddeley, Adrian and Rubak, Ege and Turner, Rolf and others},
volume={1},
year={2016},
publisher={CRC press Boca Raton}
}
@article{gunz2025analysis,
title={Analysis of anatomical multi-cellular structures from spatial omics data using sosta},
author={Gunz, Samuel and Crowell, Helena L and Robinson, Mark D},
journal={bioRxiv},
pages={2025--10},
year={2025},
publisher={Cold Spring Harbor Laboratory}
}
@article{emons2026differential,
title={Differential co-localisation analysis of multi-sample and multi-condition experiments with spatialFDA},
author={Emons, Martin and Scheipl, Fabian and Gunz, Samuel and Purdom, Elizabeth and Robinson, Mark D},
journal={bioRxiv},
pages={2026--04},
year={2026},
publisher={Cold Spring Harbor Laboratory}
}