For the following session:
session_name: foo
windows:
- layout: main-vertical
panes:
- blank
- blank
- blank
The result is:

Where the main pane is the left one, it's smaller than the others non main panes.
tmuxp load -d ./foo.yaml
- tmux 2.6/2.5
- tmuxp 1.3.5/1.3.2
- libtmux 0.7.7/0.7.1