diff --git a/sqlglot/dialects/duckdb.py b/sqlglot/dialects/duckdb.py
index 10d490934c..2ad4628d0a 100644
--- a/sqlglot/dialects/duckdb.py
+++ b/sqlglot/dialects/duckdb.py
@@ -1203,6 +1203,38 @@ def objectinsert_sql(self, expression: exp.ObjectInsert) -> str:
 
             return self.func("STRUCT_INSERT", this, kv_sql)
 
+        def startswith_sql(self, expression: exp.StartsWith) -> str:
+            this = expression.this
+            expr = expression.expression
+
+            if not this.type:
+                from sqlglot.optimizer.annotate_types import annotate_types
+
+                this = annotate_types(this, dialect=self.dialect)
+
+            if not expr.type:
+                from sqlglot.optimizer.annotate_types import annotate_types
+
+                expr = annotate_types(expr, dialect=self.dialect)
+
+            if isinstance(expression.this, exp.ByteString):
+                expression.this.replace(exp.Literal.string(expression.this.this))
+            elif this.type and not this.is_type(
+                exp.DataType.Type.VARCHAR, exp.DataType.Type.UNKNOWN
+            ):
+                expression.this.replace(exp.cast(expression.this, exp.DataType.Type.VARCHAR))
+
+            if isinstance(expression.expression, exp.ByteString):
+                expression.expression.replace(exp.Literal.string(expression.expression.this))
+            elif expr.type and not expr.is_type(
+                exp.DataType.Type.VARCHAR, exp.DataType.Type.UNKNOWN
+            ):
+                expression.expression.replace(
+                    exp.cast(expression.expression, exp.DataType.Type.VARCHAR)
+                )
+
+            return self.func("STARTS_WITH", expression.this, expression.expression)
+
         def unnest_sql(self, expression: exp.Unnest) -> str:
             explode_array = expression.args.get("explode_array")
             if explode_array:
diff --git a/tests/dialects/test_bigquery.py b/tests/dialects/test_bigquery.py
index cee8a47f9b..d637a90693 100644
--- a/tests/dialects/test_bigquery.py
+++ b/tests/dialects/test_bigquery.py
@@ -1205,6 +1205,21 @@ def test_bigquery(self):
                 "spark": "CAST(a AS BINARY)",
             },
         )
+        # Test STARTS_WITH with BYTES/BLOB handling from BigQuery to DuckDB
+        self.validate_all(
+            "STARTS_WITH(CAST('foo' AS BYTES), CAST('f' AS BYTES))",
+            write={
+                "bigquery": "STARTS_WITH(CAST('foo' AS BYTES), CAST('f' AS BYTES))",
+                "duckdb": "STARTS_WITH(CAST(CAST('foo' AS BLOB) AS TEXT), CAST(CAST('f' AS BLOB) AS TEXT))",
+            },
+        )
+        self.validate_all(
+            "STARTS_WITH(CAST('foo' AS BYTES), b'f')",
+            write={
+                "bigquery": "STARTS_WITH(CAST('foo' AS BYTES), b'f')",
+                "duckdb": "STARTS_WITH(CAST(CAST('foo' AS BLOB) AS TEXT), 'f')",
+            },
+        )
         self.validate_all(
             "CAST(a AS NUMERIC)",
             write={