diff --git a/boards/st/nucleo_h7s3l8/board.cmake b/boards/st/nucleo_h7s3l8/board.cmake
index e0005d1dc825..e8e3426630bb 100644
--- a/boards/st/nucleo_h7s3l8/board.cmake
+++ b/boards/st/nucleo_h7s3l8/board.cmake
@@ -2,6 +2,9 @@
 
 # keep first
 board_runner_args(stm32cubeprogrammer "--port=swd" "--reset-mode=hw")
+if(CONFIG_XIP AND (CONFIG_STM32_MEMMAP OR CONFIG_BOOTLOADER_MCUBOOT))
+  board_runner_args(stm32cubeprogrammer "--extload=MX25UW25645G_NUCLEO-H7S3L8.stldr")
+endif()
 
 board_runner_args(openocd --target-handle=_CHIPNAME.cpu0)
 
diff --git a/boards/st/nucleo_h7s3l8/nucleo_h7s3l8.dts b/boards/st/nucleo_h7s3l8/nucleo_h7s3l8.dts
index 2e7435bb95ce..cdccc442c2c4 100644
--- a/boards/st/nucleo_h7s3l8/nucleo_h7s3l8.dts
+++ b/boards/st/nucleo_h7s3l8/nucleo_h7s3l8.dts
@@ -57,6 +57,15 @@
 		led2 = &red_led;
 		sw0 = &user_button;
 		watchdog0 = &iwdg;
+		spi-flash0 = &mx25uw25645;
+	};
+
+	ext_memory: memory@70000000 {
+		compatible = "zephyr,memory-region";
+		reg = <0x70000000 DT_SIZE_M(64)>;
+		zephyr,memory-region = "EXTMEM";
+		/* The ATTR_MPU_EXTMEM attribut causing a MPU FAULT */
+		zephyr,memory-attr = <( DT_MEM_ARM(ATTR_MPU_IO) )>;
 	};
 };
 
@@ -189,6 +198,7 @@
 		ospi-max-frequency = <DT_FREQ_M(50)>;
 		spi-bus-width = <XSPI_OCTO_MODE>;
 		data-rate = <XSPI_DTR_TRANSFER>;
+		four-byte-opcodes;
 		status = "okay";
 
 		partitions {
diff --git a/boards/st/stm32h7s78_dk/board.cmake b/boards/st/stm32h7s78_dk/board.cmake
index 9de6ed63802b..fed92daa44d2 100644
--- a/boards/st/stm32h7s78_dk/board.cmake
+++ b/boards/st/stm32h7s78_dk/board.cmake
@@ -2,6 +2,10 @@
 
 # keep first
 board_runner_args(stm32cubeprogrammer "--port=swd" "--reset-mode=hw")
+if(CONFIG_XIP AND (CONFIG_STM32_MEMMAP OR CONFIG_BOOTLOADER_MCUBOOT))
+  board_runner_args(stm32cubeprogrammer "--extload=MX66UW1G45G_STM32H7S78-DK.stldr")
+endif()
+
 board_runner_args(openocd --target-handle=_CHIPNAME.cpu0)
 
 # keep first
diff --git a/boards/st/stm32h7s78_dk/stm32h7s78_dk.dts b/boards/st/stm32h7s78_dk/stm32h7s78_dk.dts
index d43fa8cee484..1406a07d2af3 100644
--- a/boards/st/stm32h7s78_dk/stm32h7s78_dk.dts
+++ b/boards/st/stm32h7s78_dk/stm32h7s78_dk.dts
@@ -69,6 +69,15 @@
 		die-temp0 = &die_temp;
 		volt-sensor0 = &vref;
 		volt-sensor1 = &vbat;
+		spi-flash0 = &mx66uw1g45;
+	};
+
+	ext_memory: memory@70000000 {
+		compatible = "zephyr,memory-region";
+		reg = <0x70000000 DT_SIZE_M(64)>;
+		zephyr,memory-region = "EXTMEM";
+		/* The ATTR_MPU_EXTMEM attribut causing a MPU FAULT */
+		zephyr,memory-attr = <( DT_MEM_ARM(ATTR_MPU_IO) )>;
 	};
 };
 
@@ -244,6 +253,7 @@
 		ospi-max-frequency = <DT_FREQ_M(50)>;
 		spi-bus-width = <XSPI_OCTO_MODE>;
 		data-rate = <XSPI_DTR_TRANSFER>;
+		four-byte-opcodes;
 		status = "okay";
 
 		partitions {
diff --git a/samples/application_development/code_relocation_nocopy/boards/nucleo_h7s3l8.conf b/samples/application_development/code_relocation_nocopy/boards/nucleo_h7s3l8.conf
new file mode 100644
index 000000000000..eac2504a7850
--- /dev/null
+++ b/samples/application_development/code_relocation_nocopy/boards/nucleo_h7s3l8.conf
@@ -0,0 +1,2 @@
+CONFIG_FLASH=y
+CONFIG_STM32_MEMMAP=y
diff --git a/samples/application_development/code_relocation_nocopy/boards/stm32h7s78_dk.conf b/samples/application_development/code_relocation_nocopy/boards/stm32h7s78_dk.conf
new file mode 100644
index 000000000000..eac2504a7850
--- /dev/null
+++ b/samples/application_development/code_relocation_nocopy/boards/stm32h7s78_dk.conf
@@ -0,0 +1,2 @@
+CONFIG_FLASH=y
+CONFIG_STM32_MEMMAP=y
diff --git a/samples/sysbuild/with_mcuboot/boards/nucleo_h7s3l8.overlay b/samples/sysbuild/with_mcuboot/boards/nucleo_h7s3l8.overlay
new file mode 100644
index 000000000000..7af649b38c65
--- /dev/null
+++ b/samples/sysbuild/with_mcuboot/boards/nucleo_h7s3l8.overlay
@@ -0,0 +1,17 @@
+/*
+ * Copyright (c) 2025 STMicroelectronics
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+/*
+ * Define the device, controller and partition to be the external memory
+ * for running the application in external NOR from MCUboot
+ */
+/ {
+	chosen {
+		zephyr,flash = &mx25uw25645;
+		zephyr,flash-controller = &mx25uw25645;
+		zephyr,code-partition = &slot0_partition;
+	};
+};
diff --git a/samples/sysbuild/with_mcuboot/boards/stm32h7s78_dk.overlay b/samples/sysbuild/with_mcuboot/boards/stm32h7s78_dk.overlay
new file mode 100644
index 000000000000..d5054ef5cb11
--- /dev/null
+++ b/samples/sysbuild/with_mcuboot/boards/stm32h7s78_dk.overlay
@@ -0,0 +1,17 @@
+/*
+ * Copyright (c) 2025 STMicroelectronics
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+/*
+ * Define the device, controller and partition to be the external memory
+ * for running the application in external NOR from MCUboot
+ */
+/ {
+	chosen {
+		zephyr,flash = &mx66uw1g45;
+		zephyr,flash-controller = &mx66uw1g45;
+		zephyr,code-partition = &slot0_partition;
+	};
+};
diff --git a/samples/sysbuild/with_mcuboot/sample.yaml b/samples/sysbuild/with_mcuboot/sample.yaml
index e1980ff30c1c..4a0e53d942d8 100644
--- a/samples/sysbuild/with_mcuboot/sample.yaml
+++ b/samples/sysbuild/with_mcuboot/sample.yaml
@@ -14,6 +14,8 @@ tests:
       - esp32s3_devkitm/esp32s3/procpu
       - esp32c3_devkitm
       - esp32c6_devkitc/esp32c6/hpcore
+      - nucleo_h7s3l8
+      - stm32h7s78_dk
     integration_platforms:
       - nrf52840dk/nrf52840
       - esp32_devkitc/esp32/procpu