Computational tool for carrying out KSEA analysis using formulas from Casado et al 2013. Prevously published as KSEA_Professional (Casado et al 2022).
The copyright holder for these data is the author. This resource is made available under a Creative Commons Attribution-NonCommercial-NoDerivatives CC-BY-NC-ND 4.0 International license.
Download the KSEA_plus zip file and create a shortcut to the KSEA_plus.exe program once it is opened. Run the KSEA_plus.exe program to begin analysing data.
Custom databases can be used in KSEA_plus by adding csv files into the relevent data_files folder. These csv files must have the same layout as the current databases: 1) nodes 2) number of edges in node 3) list of edges seperated by semicolon ";".
We hope this tool will be useful for you and the field. If you have any questions or ideas please contact [email protected]
Casado P, Rodriguez-Prados JC, Cosulich SC, Guichard S, Vanhaesebroeck B, Joel S, Cutillas PR. Kinase-substrate enrichment analysis provides insights into the heterogeneity of signaling pathway activation in leukemia cells. Sci Signal. 2013 Mar 26;6(268):rs6. doi: 10.1126/scisignal.2003573. PMID: 23532336..
Casado P., Hijazi M., Gerdes H., Cutillas P.R. (2022) Implementation of Clinical Phosphoproteomics and Proteomics for Personalized Medicine. In: Corrales F.J., Paradela A., Marcilla M. (eds) Clinical Proteomics. Methods in Molecular Biology, vol 2420. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1936-0_8